Blake is described by her voice actress Arryn Zech as being "mellow". She displays a cool, reserved and serious personality most of the time but does not lack a humorous side, which is usually in the form of dry wit and sarcasm. Blake is a righteous person, respecting other people's lives regardless of whether they are Faunus or not. She strongly despises those who judge and discriminate based on racial prejudice. Blake is outspoken, going so far as to indirectly insult the Schnee Dust Company in front of its heiress and defend Faunus of any kind. Despite her generally quiet demeanor, she can be surprisingly charismatic, as when she rallied the Faunus to defend Mistral against the White Fang after the attack on her home.
Blake is shown to be an introvert. Although she reads books to distance herself from the discussion at hand, as the series continues, she is shown to be more facetious and friendly. Blake appears most conversant when discussing the history and plight of her people.
As a Faunus, Blake has faced discrimination in the past and wears a bow when around Humans in order to be treated for her character and not her species. However, despite having no hate for Humans, she has seen how the real world works and wonders how she can undo so many years of hate and pain. After the Fall of Beacon, Blake discards her bow and does not cover her ears again, even around the presence of Humans, showing that she is no longer afraid to be seen as a Faunus.
Blake's past negatively influenced her personality, leading to moodiness, stubbornness, sleep deprivation and trust issues at times. She also has self-loathing issues, viewing herself as a criminal hiding in plain sight because of her past with the White Fang until her teammates convinced her that they still trusted and cared for her despite her being a Faunus and a former member of the White Fang. She also viewed herself as a coward who ran from her problems, as her Semblance was a prospect of her tendency to avoid conflict. She had even felt unworthy of her parents' love after leaving them behind for the White Fang's cause. However, her strong sense of righteousness led her to strongly disagree with the White Fang's increasing level of violence and hatred towards Humans, especially Adam's. It was thanks to her realization of seeing how spiteful and uncaring Adam was for Human lives she not only left the group but also decided to fight back after discovering Adam was planning to overthrow Sienna Khan and gain total control over the White Fang.
Thanks to her parents' unconditional love and Sun Wukong's support of her, Blake began to grow out of her self-loathing issues and mistrust for others, with Sun persuading her to let her friends help her as much as she believes she is helping them. She uses this in turn to persuade Ilia Amitola to leave the White Fang and find the courage to confront Adam with others' help and to reunite with her teammates at Haven. After she and Yang kill Adam for good, she vows to keep her promise by never running again, no longer viewing herself as a coward.
During her time at Beacon she learns to open up more and trust her teammates, and became more fun loving while hanging out with her friends, but when the Battle of Beacon happened, and Adam vowing to destroy everything she loved, she was regressed to loneliness and isolation, until Sun's persistence helps straighten out her understanding of the value and importance of having friends. After saving Haven Academy, reconciling with her teammates, and defeated Adam for good, she starts to relearn how to relax and have fun, such as going clubbing with Yang and Team FNKI.
Due to her time in the White Fang, Blake holds a bias against Atlas and its military as a whole. This is most noticeable regarding her double standard in keeping secrets. In "A New Approach", she goes along with Ruby's decision to lie to James Ironwood and keep Ozpin's disappearance, how many questions left in the Relic of Knowledge, and Salem's immortality a secret. Yet in "Worst Case Scenario", she and Yang have no trouble spilling information on the Amity Communications Tower to Robyn Hill despite Ironwood's insistence on keeping it secret, due to the former sympathizing with her nature as a vigilante. These acts are one of the reasons why Ironwood eventually loses trust in them.
Her Faunus traits also seem to give her other aspects of a cat, such as climbing up to Ruby's bed to stay away from Ruby and Yang's pet dog, Zwei. Another time, she is distracted by and instinctively decides to follow a laser pointer light to a waiting Yang in "Burning the Candle". She also has a great love for tuna, as shown in "Round One" where she drools over a bowl of noodles topped with tuna.
In “A Cat Most Curious“, when Blake’s past self offers Blake an opportunity of changing her form to either a human or a cat in order to fit in and not being discriminated, Blake declines her offer as she is done hiding for who she is and she is proud to be a Faunus. It shows on much Blake has changed and accept her status as a Faunus as she has many people who treated her equally.